Express Scripts SafeGuardRx®

A Platform and A Promise

Our multi-program SafeGuardRxSM platform is continuously evolving to expose new opportunities in critical disease states.

Our Platform

First‑to‑market.
Value‑based.

SafeGuardRx combines our specialized clinical model and value-based contracting strategies to help plans improve patient care for the toughest conditions while also controlling costs.

Our Promise

Continuing to improve outcomes and increase value.

SafeGuardRx unlocks increasingly greater clinical and financial value for plans and better outcomes for patients over time – providing a new peace of mind by reducing risk, cost and waste.

50 million

lives covered

9

specialty and chronic
classes covered

Deploys

clinically appropriate,
cost-effective strategies

$2.4 billion

saved in 2018

SafeGuardRx Savings Calculator

Find out how much you could save with SafeGuardRx

Keep scrolling to learn more about the value SafeGuardRx delivers.

Solving Healthcare’s Most Complex Clinical
and Financial Challenges with SafeGuardRx

Better Care. Better Value.

It’s no secret that care for the most complex and challenging disease states must be improved and costs must be more effectively managed. SafeGuardRx is proven to do both in a single platform.

By enrolling in SafeGuardRx, you’re helping your members experience better medication adherence, higher therapy completion rates and greater compliance with clinical guidelines – without the risk, or concern, of the loss of financial value.

SafeGuardRxSM proves plans can achieve better health and increased savings
– without tradeoffs.

Pioneering the Evolution of Care

While others were still theorizing about solving healthcare’s toughest challenges, we got to work – applying our scale, rigor and tenacity to create a platform that is the best possible way for plans to deliver personalized care while keeping costs in check. Each year, SafeGuardRx delivers better outcomes and increased value. We continue to take on the most complex, highest-cost challenges in healthcare and, in 2018 alone, SafeGuardRx helped enrolled clients save more than $2.4 billion.

Click the icons to learn about the impact of the SafeGuardRx programs:

Click the arrows to learn about the impact of the SafeGuardRx programs:

  • HEPATITIS CURE VALUESM
  • CHOLESTEROL CARE VALUESM
  • ONCOLOGY CARE VALUESM
  • INFLATION PROTECTIONSM
  • INFLAMMATORY CONDITIONS CARE VALUESM
  • DIABETES CARE VALUESM
  • MARKET EVENTS PROTECTIONSM
  • MULTIPLE SCLEROSIS CARE VALUESM
  • PULMONARY CARE VALUESM
  • RARE CONDITIONS CARE VALUESM
  • MIGRAINE CARE VALUESM

Delivers personalized care for complex
chronic and specialty conditions

Tackles market challenges
to deliver lower overall costs

  • Helps lower the cost of
    a cure
    for hepatitis C

    Expands access to curative
    therapy to thousands of people

  • Delivers maximum value
    for PCSK9 inhibitors

    Enrolled clients see lower
    costs per patient
    than
    those not enrolled

  • Aligns the cost of oncology
    medications with outcomes

    Personalized medicine through
    genetic testing
    puts even more information in the patient’s and physician’s hands

  • Shields plans from the
    full cost impact of excessive
    year-over-year price increases on brand drugs

    Leverages the power of our
    existing drug contracts to provide
    more value and budget predictability

  • Segments therapies by indication
    for inflammatory conditions to drive
    to lower overall costs

    Specialized care leads to
    lower therapy discontinuation rates

  • Motivates patients and delivers
    healthier outcomes through patient engagement technologies

    High-touch support from
    Diabetes Therapeutic Resource
    CenterSM clinicians

    Download Executive Brief
  • Protects against extreme price
    increases, unwarranted price discrepancies and patent expirations

    Drives members to the most
    clinically appropriate, cost-effective therapies or dispensing channels

  • Delivers specialized clinical
    support and client savings
    due to increased adherence

    Express Scripts shares your risk with early discontinuation reimbursements
    for preferred MS medications

    Download Infographic
  • Unites specialized support and
    patient engagement tools for holistic management of asthma and COPD

    Lowers net cost of treatment

    Download Infographic
  • Protection from unexpected,
    staggering costs
    of rare conditions,
    which affect 30M people in the U.S.
    – the same number battling diabetes

    Guides patients with rare conditions
    to the most effective care pathway

    Watch Video
  • Drives savings on high-cost,
    breakthrough CGRP-inhibitor
    medications

    Provides specialized clinical support
    through our Neuroscience
    Therapeutic Resource CenterSM

    Watch Video
  • SAFEGUARDRx PROGRAM

    Delivers personalized care for complex chronic and specialty conditions

    Tackles market challenges to deliver lower overall costs

  • HEPATITIS CURE VALUESM

    Helps lower the cost of
    a cure
    for hepatitis C

    Expands access to curative therapy to thousands of people

  • CHOLESTEROL CARE VALUESM

    Delivers maximum value for PCSK9 inhibitors

    Enrolled clients see lower costs per patient than those not enrolled

  • ONCOLOGY CARE VALUESM

    Aligns the cost of oncology medications with outcomes

    Personalized medicine through genetic testing puts even more information in the patient’s and physician’s hands

  • INFLATION PROTECTIONSM

    Shields plans from the full cost impact of excessive year-over-year price increases on brand drugs

    Leverages the power of our existing drug contracts to provide more value and budget predictability

  • INFLAMMATORY CONDITIONS CARE VALUESM

    Segments therapies by indication for inflammatory conditions to drive
    to lower overall costs

    Specialized care leads to lower therapy discontinuation rates

  • DIABETES CARE VALUESM

    Motivates patients and delivers healthier outcomes through patient engagement technologies

    High-touch support from Diabetes Therapeutic Resource
    CenterSM clinicians

    Download Executive Brief
  • MARKET EVENTS PROTECTIONSM

    Protects against extreme price increases, unwarranted price discrepancies and patent expirations

    Drives members to the most clinically appropriate, cost-effective therapies or dispensing channels

  • MULTIPLE SCLEROSIS CARE VALUESM

    Delivers specialized clinical support and client savings due to increased adherence

    Express Scripts shares your risk with early discontinuation reimbursements for preferred MS medications

    Download Infographic
  • PULMONARY CARE VALUESM

    Unites specialized support and patient engagement tools for holistic management of asthma and COPD

    Lowers net cost of treatment

    Download Infographic
  • RARE CONDITIONS CARE VALUESM

    Protection from unexpected, staggering costs of rare conditions,
    which affect 30M people in the U.S. – the same number battling diabetes

    Guides patients with rare conditions to the most effective care pathway

    Watch Video
  • MIGRAINE CARE VALUESM

    Drives savings on high-cost, breakthrough CGRP-inhibitor medications

    Provides specialized clinical support through our Neuroscience Therapeutic Resource CenterSM

    Watch Video

Fulfilling Our Promise as
Champions For Better

At the heart of SafeGuardRx is our unwavering belief that within the most complex and expensive healthcare issues exists the greatest opportunity for improvement. We are working with participating plans to harness that opportunity through this platform. As Champions For Better, we take on the risk of managing clinical and financial challenges – and hold the entire healthcare marketplace accountable – in a way that others don’t, won’t or can’t.


To learn more about how SafeGuardRx can help you deliver better care and better value contact your Express Scripts account team or email us now.